Description
PDCD4, also known as Programmed cell death 4, encodes a tumor suppressor protein whose expression is lost in progressed carcinomas of lung, breast, colon, and prostate. The expression of PDCD4 gene is strongly induced during apoptosis in a number of cell types. It is modulated by cytokines in natural killer and T cells. Recombinant human PDCD4, was expressed in E Coli and purified by conventional chromatography techniques